Lynch syndrome Module 3 training test for Gynae MDT

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1. What is your name? *

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2. What does it mean if the MMR IHC results are normal?
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Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing

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3. If the MMR IHC results show that there is isolated loss of PMS2, what does it mean?
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Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing

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4. If the IHC result show that there is a loss of MLH1 and PMS2, what does it mean? *

Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing

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5. If the MMR IHC result show that there is loss of MSH2 and MSH6, what does it mean?
*

Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing

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6. The MMR IHC result showed that there is loss of MLH1. You ordered further MLH1 Methylation in the tumour sample. The result shows that there is "abnormal MLH1 methylation" present (methylation is present). What does it mean? *

Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is likely - Ask the lab to repeat the test
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing

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7. The MMR IHC result show that there is loss of MLH1. The MLH1 promoter hypermethylation shows: "MLH1 promoter methylation is not detected". What does it mean? *

Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is likely - Ask the lab to repeat the test
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history
Diagnosis of Lynch syndrome is likely - Offer genetic testing

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