Lynch syndrome Module 3 training test

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1. What is your name? *

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2. What does it mean if the MMR IHC results are normal? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation or BRAF test
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

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3. Is the MMR IHC results show that there is isolated loss of PMS2, what does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation or BRAF test
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

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4. If the IHC result show that there is a loss of MLH1 and PMS2, what does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation or BRAF test
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

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5. If the MMR IHC result show that there is loss of MSH2 and MSH6, what does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation or BRAF test
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

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6. The MMR IHC result showed that there is loss of MLH1. You ordered further MLH1 Methylation in the tumour sample. The result shows that there is "abnormal MLH1 methylation" present (methylation is present). What does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation or BRAF test
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

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7. The MMR IHC result show that there is loss of MLH1. The BRAF results are now back. It shows that the tumour sample is not BRAF mutant (also called absent or wild type). What does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation or BRAF test
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider

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