Lynch syndrome Online training for pathologists M1 CRC

1. What is your name? *

2. What is your job title? *

3. In which Hospital and Trust do you work? *

4. What is your email address? *

5. What is your cancer alliance? *

6. What is your GMSA? *

7. Why are you undertaking this training? *

8. Which MDT do you work with? *

Colorectal cancer
Endometrial cancer
Both

9. What does it mean if the MMR IHC results are normal? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation or BRAF test

10. Is the MMR IHC results show that there is isolated loss of PMS2, what does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation or BRAF test

11. If the IHC result show that there is a loss of MLH1 and PMS2, what does it mean? *

Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation or BRAF test

12. If the MMR IHC result show that there is loss of MSH2 and MSH6, what does it mean? *

Diagnosis of Lynch syndrome is possible - Order MLH1 promoter Methylation or BRAF test
Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC

13. The MMR IHC result showed that there is loss of MLH1. You ordered further MLH1 Methylation in the tumour sample. The result shows that there is "abnormal MLH1 methylation" present (methylation is present). What does it mean? *

Diagnosis of Lynch syndrome is likely - Order BRAF test
Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC

14. The MMR IHC result show that there is loss of MLH1. The BRAF results are now back. It shows that the tumour sample is not BRAF mutant (also called absent or wild type). What does it mean? *

Diagnosis of Lynch syndrome is likely - Order MLH1 promoter Methylation
Diagnosis of Lynch syndrome is likely - Offer genetic testing
Diagnosis of Lynch syndrome is unlikely - Nothing further to consider
Diagnosis of Lynch syndrome is unlikely - Refer to genetics if there is a significant family history or early onset of CRC

15. When would you use this report?
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16. When would you use this report?
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17. When would you use this report?
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